![]() Platelet distribution width (PDW) is another indicator of platelet activation. Platelet activation has been thought to play a triggering role in arterial disorders, and mean platelet volume (MPV) is considered a good indicator of platelet activation. It has been suggested that thrombocyte activation has an important role in the pathogenesis of atherosclerosis in various inflammatory diseases. ![]() ![]() Because it is associated with atherosclerosis, the diagnosis of subclinical inflammation has become more important. Subclinical inflammation can also be observed in FMF. Colchicine treatment has been shown to be effective in preventing the development of amyloidosis and in reducing proteinuria. The disease is common in Mediterranean countries, and the incidence of the disease has been reported as 1/200 in Ashkenazi Jews and 1/1000 in Turks. Familial Mediterranean fever (FMF) is an inherited disease characterized by recurrent attacks of serositis, fever, and erysipelas-like skin rash.
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